Stoutnessis an expanding significant general wellbeing concern requesting dietary procedures to restrict weight acquires and related comorbidities. In this survey, we present creature models, especially rodents and mice, which have been widely utilized by researchersto comprehend the outcomes of diet quality on weight gain and wellbeing. Strikingly, adjustment of dietary protein amount and additionally quality has been displayed to apply colossal consequences for body structure homeostasis through the tweak of food consumption, energy use, and metabolic pathways. Strangely, the perinatal window seems to address a basic period during which the protein admission of the dam can affect the posterity's weight gain and taking care of conduct. Creature models are additionally generally used to comprehend the cycles and systemsthat add to corpulence at various physiological and pathophysiological stages. A fascinating illustration of such perspective is the circumstance of diminished oestrogen level happening at menopause, which is connected to weight acquire and diminished energy consumption. To contemplate metabolic problems related with such circumstance, estrogen withdrawal in ovariectomized creature models to imitate menopause are every now and again utilized. As per many examinations, clear species-explicit contrasts exist among rodents and mice that should be considered when results are extrapolated to people.